Nucleosides and Analogues
Medchemexpress LLC Motesanib diphosphate | 857876-30-3 | MFCD12407403 | 99.9% | 569.44 g/mol | C22H29N5O9P2 | 5 MG
Motesanib diphosphate is the diphosphate salt of motesanib, an ATP-competitive inhibitor of VEGFR1/2/3 and c-Kit, supplied for laboratory research and analytical applications.
- Potent ATP-competitive inhibitor of VEGFR1/2/3 and c-Kit.
- Molecular formula: C22H29N5O9P2.
- Molecular weight: 569.44 g/mol.
- Pack size: 5 mg.
- Solubility: DMSO ≥ 110 mg/mL; H2O 5 mg/mL (with ultrasonic warming).
- Storage: 4°C sealed; in solvent -80°C (6 months), -20°C (1 month).
- For research use only; not for human or veterinary use.
Medchemexpress LLC Adenosine 5'-O-(2-thiodiphosphate) trilithium salt | 73536-95-5 | MFCD00077314 | 94.9% | C10H12Li3N5O9P2S | 10MG
ADP-β-S trilithium is the trilithium salt of adenosine 5'-β-thiodiphosphate, used in research as a P2Y12 receptor activator. It is supplied as a white to off-white solid (CAS 73536-95-5) with listed purity ~94.9% and molecular formula C10H12Li3N5O9P2S. Store sealed and away from moisture; in solution store at -80°C for long-term stability.
- Activator of P2Y12 receptor in cellular assays.
- Upregulates IL-1β and IL-6 production in microglial models.
- Promotes NF-κB phosphorylation and nuclear translocation.
- Enhances NLRP3 inflammasome activation in relevant studies.
- Provided as a solid suitable for preparation of assay solutions.
- Stable under recommended sealed, low-temperature storage conditions.
Medchemexpress LLC Adenosine 5'-β-thiodiphosphate trilithium salt | 73536-95-5 | MFCD00077314 | 94.9% | 461.07 g·mol⁻¹ | C10H12Li3N5O9P2S | 5 MG
ADP-β-S trilithium is the trilithium salt form of adenosine 5'-β-thiodiphosphate used as a research reagent to activate P2Y12 receptors and study purinergic signaling and inflammatory pathways. It modulates cytokine production and NF-κB/NLRP3 signaling, and is provided as a dry powder for laboratory use.
- Activates P2Y12 receptor to modulate purinergic signaling.
- Increases IL-1β and IL-6 production in microglial cells.
- Promotes NF-κB phosphorylation and nuclear translocation.
- Enhances NLRP3 inflammasome activation.
- Supplied with stated purity and molecular data for experimental planning.
- Suitable for biochemical and cellular assays requiring receptor activation.
Medchemexpress LLC Uridine 5'-(trihydrogen diphosphate), 4-oxime | 39023-73-9 | 98.8% | 419.18 | 10 MG
NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) in a diphosphate form. NHC is a pyrimidine ribonucleoside and acts as a potent anti-virus agent, effectively inhibiting the replication of Venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV), and hepatitis C virus (HCV).
- Active phosphorylated intracellular metabolite
- Potent anti-virus agent
- Inhibits replication of Venezuelan equine encephalitis virus (VEEV)
- Inhibits replication of Chikungunya virus (CHIKV)
- Inhibits replication of hepatitis C virus (HCV)
- For research use only
- Soluble in H2O: 160 mg/mL (needs ultrasonic)
- Store at -20°C, protect from light, stored under nitrogen
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 100mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
eMolecules 990-91-0 | Tetrabenzyl Pyrophosphate | AA Blocks LLC | MFCD00051941 | 538.473 | C28H28O7P2 | 0.000 | O=P(OCc1ccccc1)(OCc1ccccc1)OP(=O)(OCc1ccccc1)OCc1ccccc1 | 5g | 436007791
Tetrabenzyl Pyrophosphate | AA Blocks LLC | 990-91-0 | MFCD00051941 | 538.473 | C28H28O7P2 | 0.000 | O=P(OCc1ccccc1)(OCc1ccccc1)OP(=O)(OCc1ccccc1)OCc1ccccc1 | 5g | 436007791
Medchemexpress LLC Sonidegib diphosphate | 1218778-77-8 | 99.9% | 681.49 | 50 MG
Sonidegib diphosphate is a potent and selective Smoothened (Smo) antagonist that reduces the expression of downstream Hedgehog (Hh) signaling targets. It demonstrates dose-related antitumor activity in various preclinical models and is currently undergoing clinical trials for conditions such as Basal Cell Carcinoma and Hepatocellular Carcinoma.
- Potent and selective Smoothened (Smo) antagonist
- Reduces expression of downstream Hedgehog (Hh) signaling targets
- Inhibits Hh pathway in CD34+ chronic phase (CP)-chronic myeloid leukaemia (CML) cells
- Demonstrates dose-related antitumor activity in medulloblastoma models
- Undergoing clinical trials for various conditions
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 10mM (in 1mL DMSO)
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
TARGETMOL CHEMICALS INC ADENOSINE ANTAGONIST-1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Adenosine antagonist-1 acts as an adenosine A3 receptor (AA3R) antagonist. purity: 99%
Medchemexpress LLC Potassium diphosphate | 7320-34-5 | MFCD00011393 | 1kg
Potassium diphosphate (tetra-Potassium pyrophosphate) is a kind of biological materials or organic compounds that are widely used in life science research[1]
Medchemexpress LLC Tenofovir diphosphate disodium | 2738719-07-6 | 99.42% | 491.14 | 1 MG
Tenofovir diphosphate disodium is an antiretroviral agent primarily used for AIDS research. It acts as an inhibitor of HIV reverse transcriptase DNA (Ki = 1.55 μM) and RNA (Ki = 0.022 μM). This compound exhibits minimal inhibitory effect on eukaryotic DNA replication in vitro.
- Antiretroviral agent
- Inhibits HIV reverse transcriptase DNA and RNA
- Used for AIDS research
- Minimal inhibitory effect on eukaryotic DNA replication in vitro
Medchemexpress LLC Cidofovir diphosphate tri(triethylamine) | 00-00-0 | 99.9% | 742.72 g/mol | C26H61N6O12P3 | 5 MG
Cidofovir diphosphate tri(triethylamine) is the triethylamine salt of cidofovir diphosphate, an active intracellular metabolite and selective inhibitor of viral DNA polymerases. It is provided as a high-purity biochemical reagent intended for in vitro and biochemical research applications.
Apexbio Technology LLC Primaquine Diphosphate 63-45-6 10mM (in 1mL DMSO)
Primaquine Diphosphate is an 8-aminoquinoline derivative utilized primarily as an antimalarial agent targeting the extraerythrocytic liver stage of malaria parasites While its precise IC50 values remain unspecified primaquine s biological activity involves interference with nucleic acid function subsequently disrupting protein synthesis pathways and lipid biosynthesis and inducing membrane disturbances In vitro primaquine has been applied in cell culture models to investigate antiviral effects demonstrating dose-dependent inhibition of Newcastle disease virus replication and modulation of viral RNA synthesis In vivo experiments using radiolabeled primaquine-loaded liposomes in murine models illustrate pronounced hepatic accumulation Clinically this compound is employed as prophylaxis against malaria infections (e g Plasmodium falciparum and P vivax)
Apexbio Technology LLC Motesanib Diphosphate (AMG-706) 857876-30-3 100mg
Motesanib Diphosphate (AMG-706 CAS 857876-30-3) is an oral small-molecule ATP-competitive inhibitor that targets vascular endothelial growth factor receptors (VEGFR1/2/3) platelet-derived growth factor receptor (PDGFR) c-Kit and Ret with reported IC50 values of 2 84 nM It demonstrates over 1000-fold selectivity for VEGFRs relative to EGFR Src and p38 kinases In vitro Motesanib Diphosphate potently inhibits VEGF-induced proliferation of human endothelial cells (IC50 10 nM) and blocks PDGF- and SCF-induced signaling while showing minimal effects on bFGF-stimulated proliferation In preclinical studies it suppresses angiogenesis and induces regression in tumor xenograft models Motesanib is under investigation in anti-angiogenic cancer research